Experimental Technological Laboratory
Experimental and Production Laboratory
Head of the laboratory
Doctor of Chemical Sciences
Matchanov A.D.
History
The experimental and production laboratory was founded in 1973. Throughout its existence, the laboratory was headed by Ishbaev A.I., Candidate of Chemical Sciences, Kakharov A.K., Doctor of Economic Sciences, Khaitbaev Kh.Kh., Candidate of Chemical Sciences, Saidakhmedov U.A., Doctor of Technical Sciences, Tashmukhamedov M.S., Doctor of Chemical Sciences and Prof. Mavlyanov S.M., Doctor of Chemical Sciences. There is a pilot production where the preproduction runs of preparations developed in accordance with the production techniques are manufactured on the pilot machines. The pilot production was founded in 1981, starting to function as a part of the experimental and production laboratory since 1994. Yusupov A.Sh., (1980-1987), Inogamov K (1987-1989), Isaev N.Kh. (1990-1994) and Abdurakhmanov Sh.D. (1994-1996) were at the head of the pilot production. A waste-free production technique for the efficient preparations from the Uzbekistan fat-and-oil industry by-products was developed. As the result, method for production of an emulsifier for the invert emulsion mud (Isaev Kh.I., Abdurakhmanov A.S.), as well as a process for production of gossypol tar serving as the basis for preparations OGS-5 and IKM-1 with anti-viral activity for the potato and tomato viruses were developed. Isaev Kh.I., and Yusupov A.Sh. developed a method for production of the suspended sulfur to control spider mite. Extensive efforts were made to develop a production technique for isolation of gossypol from the cotton seeds and technical gossypol, pharmacopiel gossypol, anthranilate gossypol, gossypol-acetic acid from the technical gossypol by the cold pressing (Ibragimov A.S., Otargaliev T., Saidakhmedov U.A., Salikhov Sh.I.). Methods for synthesis of the lupinine derivatives with high inhibiting activity for hydrolytic enzymes and various antiarrhythmic effects (Khaitbaev Kh.Kh., Abduvakhabov A.A.) were developed at the laboratory. The simplified production procedures were developed for substances of gossypol, betriden and megosin (Saidakhmedov U.A., Ibragimov A.S) as well as those for synthesis of pheromones of cotton budworm and turnip moth (Kholbekov O.Kh.).
Traditionally, the laboratory deals with development and introduction into practice of production procedures for preparations generated at the Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, for medicine, food industry and others. For the last years, supervised by Prof. Mavlaynov S.M. the studies on chemical composition of polyphenols from more than 120 plants were conducted. The chemical composition and biological activity of the compounds isolated to generate a number of efficient anti-viral medications.
Principle direction of research includes
- Development of knowledge intensive, import-substituting and export-oriented technology for production of preparations generated at the Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, for medicine, agriculture and food industry
- Study on qualitative and quantitative composition of polyphenols, plant terpenoids; isolation of compounds from them with identification of their structures and biological activity
- Identification of correlation between the structures of the compounds and their biological effects; generation of medications with wide profile of actions; use of polyphenols, di- and triterpenoids in other spheres of national economy
Direction of research includes
- Development of production procedure for highly gossypol cotton oil, generation of pharmacopoeil gossypol and gossypol-acetic acid from the technical gossypol
- Production of the cotton budworm pheromones and sets of pheromone traps
- Search for local promising polyphenol-containing plants, for optimal methods to isolate polyphenol compounds, as well as study on chemical structures and biological activity of the compounds isolated
- Generation and production of unique anti-viral, hypoglycemic medications from the plant polyphenols
- Development of unique efficient hemostatics on the basis of the local plant raw materials
Main achievements include
- Development of procedures for industrial production of highly gossypol cotton oil, technical gossypol from the highly gossypol industrially produced cotton oil, generation of pharmacopoeil gossypol and gossypol-acetic acid, highly refined “Yogdu” cotton oil, meeting worldwide standard requirements by chromaticity; an anti-viral 1% gossypol liniment, “Megosin” as an anti-herpetic ointment, “Rutan” as anti-flu medication; development and production of the cotton budworm pheromone and sets of pheromone traps; low gossypol cotton oilseed residues
- Study on chemical compositions of polyphenols from more than 120 plants from Annacardeaceae, Geranaceae, Punicaceae, Malvaceae families and others. More than 200 agents were isolated, more than 40 of them turned out new compounds never described in the literature
- Development of efficient methods for disintegration of the hydrolyzed tanins. The correlation between compositions and number of phenol compounds of cotton and their resistance to diseases and insect pests was established. Presence of glycosides of cyanidins and glycosides of delphinidins was identified typical for plants of Gossipium genus and hybrid forms of hibiscus,respectively
- Pioneer study on compositions of polyphenols from 29 plants belonging to the Euphorbiaceae family to isolate more than 70 phenolic compounds. By means of physical-chemical methods, the structures of the compounds were identified, 8 of them turned out new compounds never described in the literature. Having high antioxidant and anti-radical activity, the compounds in question were found not to cause a destruction of biomembranes. The antioxidant activity of the compounds was found to depend on the number of hydroxyl groups in a molecule, on their relationships, as well as on the degree of saturation and galloylation of C ring
- Demonstrating the highest anti-viral activity, the compounds isolated from the plants belonging to the Euphorbiaceae family 1-0-galloyl-2,4-valoneyl-3,4-hexahydroxydiphenyl-β-D-glucose, 3-0-galloyl-1,2-valoneyl-β-D-glucose, 2-0-galloyl-4,6-valoneyl-β-D-glucose, 1,2-di-0-galloyl-4,6-valoneyl-β-D-glucose seem to effectively inhibit HIV-infection. Mechanism of counteraction of the compounds studied, the anti-viral activity of the first compound was found to be associated with the blocking of the proviral DNA integration into the cell genome, the rest compounds prevent the interaction of the virus and the target cell
- Study on physical-chemical parameters of rutan, gossitan, getasan, punitan and euforbin as per requirements of the State Pharmacopoeia; the reference standards and the pharmaceutical forms were chosen. The complete preclinical pharmaco-toxicological tests were performed. The draft temporal pharmacopoeil monographs for substances, reference standards and pharmaceutical forms, to name rutan 0.025, gossitan 0.025, getasab 0.01, punitan 0.01 and euforbin 0.025 were prepared. The clinical tests for rutan, gossitan and getasan won the approval by the State Center for Examination and Standardization of Drugs, Medical Accessories and Medical Equipment, Uzbekistan Public Healthcare Ministry. The Republic of Uzbekistan patents were obtained for rutan and gossitan as the anti-flu medications, getasan and punitan as the medications with anti-HIV effects
- Pioneer isolation and study on more than 20 compounds, including 7 flavonoids, 9-phenolic acids and 8 hydrolyzing tannins from plants of P. major L., P. lanceolata L.genus. Chemical structures of two new hydrolyzing tannins from P. major L. were studied and proved; the chemical structure of novel tannin from P. lanceolata L. was identified; the isolated compounds were proved to have anti-inflammation and hypoglycemic activity. Anti-inflammation activity of “Plantagin” isolated from P. major L. was identified, the anti-exudative activity higher than the one of the control by 70% was found as well. “Plantagin” was proved to have the hypoglycemic effect. The patent application “An antidiabetic medication” was filed (JAP 2016 0404, 29.09.2016). “Plantagin” was found to belong to V class of low-toxic compounds with LD508900 mg/kg. Having hypoglycemic and anti-exudative effects, the medication facilitates generation of novel efficient anti-inflammation and anti-diabetic medications
- Pioneer isolation of 1 phenolic acid, 5 flavonols and 10 hydrolyzing tannins from Е. franchetii (B.Fedtsch), Е.сanescens (L.), E. humifusa (Willd.) plants for their chemical structures to be identified. 3 hydrolyzing tannins isolated from the objects of study turned out novel natural compounds; their chemical structures were proved. Biological studies demonstrated their antioxidant and anti-hypoxant effects. At the concentrations of 10 μM the polyphenols were found to completely inhibit lipid peroxidation. On the models of normobaric and hemic hypoxia the polyphenolic compounds were found to prolong mean lifetime of experimental animals demonstrating anti-hypoxic properties. Pharmaco-toxicological methods were used to demonstrate that the compounds in question belong to low toxic agents to be the basis for generation of antioxidant and anti-hypoxic medications
- Development of “Inebrin”, an effective hemostatic, based on the Lagochilus Inebrians. The substance was developed jointly with the Institute of Chemistry of Plant Compounds, Uzbekistan Academy of Sciences. The pharmaceutical tablet form is produced at the pilot production of the Institute of Bioorganic Chemistry
- Generation of a number of supramolecular complexes with high hemostatic effects, based on lagichilin, a diterpenoid. The appropriate technical and regulatory documentation for substance and hemostatic pharmaceutical forms as tablets, solutions for intravenous injections, collagen films, ointments and suppositories were developed. Clinical trials were conducted, the production permits were won.
- Production procedure for highly gossypol oil was introduced CASK Oil Division Joint Venture. The pharmacopoeil gossypol and gossypol acetic acid are produced at the pilot production of the Institute of Bioorganic Chemistry
- The cotton bud worm pheromones and sets of pheromone traps are widely used at the cotton fields of Uzbekistan
- Production procedure of low gossypol oil seed residues was introduced at 11 fat and oil facilities of Uzbekistan
- “Rutan”, an anti-viral and interferon inducing medication was introduced into medical practice winning the permit for production and wide medical use (Certificate 01-14); pharmacopoeil monographs for the reference standard (42 Uz-251402018), for substance (42 Uz-2515-2018), pharmaceutical form (temporal pharmacopoeil monograph 42 Uz-2516-2015) were approved. The registration certificate was obtained for “Rutan” (temporal pharmacopoeil monograph DV/M 00339/09/15). Manufacturing specifications were approved for “Rutan” tablets production
- Permit for clinical trials for “Gossitan”, an anti-flu medication, and “Getsan”, an anti-HIV medication was obtained
- Preclinical pharmaco-toxicological studies were completed, a document package was submitted to the Pharmaceutical Committee for clinical studies on “Providin”, an anti-hypoxic medication, and “Euforbin” anti-HIV medication to be permitted
Research results (patents, certificates, temporal pharmacopoeil monographs, and pharmaceutical forms) include
- Pharmacopoeil monographs for the “Rutan” reference standard (42 Uz-2514-2018), substance (42 Uz-2515-2018), and pharmaceutical form (temporal pharmacopoeil monograph 42 Uz-2516-2015). Manufacturing specifications were approved for “Rutan” tablets production
- “Rutan” substance, reference standard and pharmaceutical form won the permit of the State Center for Examination and Standardization of Drugs, Medical Accessories and Medical Equipment, Uzbekistan Public Healthcare Ministry (No.01-14, dated May 08, 2014) to be used in medical practice
- Temporal pharmacopoeil monograph for “Lagovin” substance No. 42 Uz-3120-2017 (Salikhov Sh.I., Dalimov D.N., Matchanov A.D., Gafurov M.B., Vypova N.L.)
- Temporal pharmacopoeil monograph for “Glylagin” substance No. 42 Uz-3120-2017 (Salikhov Sh.I., Dalimov D.N., Matchanov A.D., Gafurov M.B., Vypova N.L.)
- Temporal pharmacopoeil monograph for “Glylagin” tablets No. 42 Uz-3405-2018 (Salikhov Sh.I., Dalimov D.N., Matchanov A.D., Gafurov M.B., Vypova N.L., Islomov A.Kh., Usubbaev A.M.)
- Temporal pharmacopoeil monograph for “Inebrin” substance No. 42 Uz-2535-2018 (Salikhov Sh.I., Zainutdinov U.N., Dalimov D.N., Matchanov A.D., Islamov A.Kh., Aliev Kh.U., Abdullaev N.D., Bobkulov Kh.M.)
- Pharmacopoeil monograph for “Inebrin 200mg” tablets No. 42 Uz-2536-2018 (Salikhov Sh.I., Zainutdinov U.N., Dalimov D.N., Matchanov A.D., Vypova N.L., Islamov A.Kh., Aliev Kh.U., Usubbaev M., Usubbaev A.M., Abdullaev N.D., Bobokulov Kh.M.)
- Temporal pharmacopoeil monograph for “Glycyram” substance No. 42 Uz-2369-2013 (Turaev A.S.,, Dalimov D.N., Matchanov A.D., Gafurov M.B., Vypova N.L.)
Services include
- Study on qualitative and quantitative compositions of plant polyphenols
- Isolation of substances for medications
- Cotton oil refining
- Distilling over and production of concentrates for any solutions and extracts
- Production of pharmacopoeil gossypol and gossypol acetic acid
- Production of sets of pheromone traps to control cotton budworm and turnip moth
Prospects include
- Generation of 10.0 kg of “Rutan” substance for the “Rutan 0.025” No.20 pharmaceutical form to be produced in amounts of 20,000 units
- Generation of 200 kg of GUK, its certification and export
- Delivery order and installation of new foreign equipment for the laboratory to produce pilot lots of the substances and pilot plant equipment for the work shop
- Completion of studies on Gossitan, Getasan, Euforbin, Plantagin; winning of the permit for clinical trials; clinical trials and permit for use in medical practice
- Generation of 10 kg of the glycyram substance, a monoammonium salt of glycerrhyzic acid. Production of the glycyram 0.05g tablets
- Generation of 1.5 kg of Glylagin substance, hemostatic preparation. Production of 0.005 g Glylagin tablets
- Search for phenol compounds and their isolation from plants of Uzbekistan, identification of their structure and biological activity (anti-viral, antioxidant, hypoglycemic, etc). Selection of the most active compounds for comprehensive study aiming at generation of effective medications on their basis. Identification of correlation between the structures of the compounds and their anti-viral activity; generation of the grounds for purpose-oriented search of compounds of polyphenolic origin with anti-viral effects
- Search for novel promising substances based on the plant extracts and their components from the local raw materials – modulators of cell volume regulations and volume-related membrane transport. Screening of membrane-active, hypoglycemic, anti-hypoxic, cyto-, neuro- and cardio-protective properties of polyphenol compounds (jointly with Institute of Biophysics and Biochemistry)
- Synthesis of novel promising biologically active agents on the basis of lagochilin and its derivatives; study on their biological activities
- Industrial production of soft pharmaceutical forms of Glylagin as gels and suppositories
- Development of Lagovin capsules and tablets
Scientific ties
- Belostok State University, biophysics department
- Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
- Institute of Theoretical and experimental Biophysics, Russian Academy of Sciences
- D.I. Ivanovskyi Institute of Virology, Russian Medical Academy of Sciences
- Institute of Virology, Uzbekistan Public Healthcare Ministry
- Tashkent Pharmaceutical Medical Institute, Uzbekistan Public Healthcare Ministry
- Tashkent Medical Academy
International grants
Uzbek-Russian project “Mechanisms of inhibition of viral replication of plant polyphenols” (2008-2010)
Research staff (photo)
- Professor Abdulladjanova N.G., Doctor of Chemical Sciences
- Nabiev A.Kh., senior researcher, Candidate of Technical Sciences
- Kholbekov O.Kh., senior researcher, PhD (Chemistry)
- Makhmudov R.R., senior researcher, PhD (Chemistry)
- Rakhimov R.N., senior researcher, PhD (Chemistry)
- Islamov A.Kh., senior researcher, PhD (Chemistry)
- Sobirova F.A. research assistance
- Ibragimov A.I., junior researcher
- Rasulov A.Kh. junior researcher
Patents
- Patent UZ № IАР 2010 0392, 11.04.2012. Salikhov Sh.I., Mavlyanov S.M., Karamov E.V., Abdulladjanova N.G., Kornilaeva G.V., Sidorovich I.G., Khaitov R.M. “A medication demonstrating anti-HIV activity”.
- Patent UZ № IАР 2010 0393, 11.04.2012. Salikhov Sh.I., Mavlyanov S.M., Karamov E.V., Abdulladjanova N.G., Kornilaeva G.V., Sidorovich I.G., Khaitov R.M. “A medication demonstrating anti-HIV activity”.
- Patent UZ № IАР 2010 0390, 16.05.2012. Salikhov Sh.I., Mavlyanov S.M., Karamov E.V., Abdulladjanova N.G. “A medication demonstrating anti-flu effect”.
- Patent UZ № IАР 2010 0391, 16.05.2012. Salikhov Sh.I., Mavlyanov S.M., Karamov E.V., Abdulladjanova N.G. “A medication demonstrating anti-flu effect”.
- Patent UZ № IАР 2010 0563, 23.07.2012. Mavlyanov S.M., Abdulladjanova N.G., Shamuratov B.A., Dalimov d.N., Salikhov Sh.I.“A medication demonstrating anti-tumor activity”.
- Patent UZ № IАР 2010 0477, 18.06.2012. Mavlyanov S.M., Abdulladjanova N.G., Pirniyazov A.J., Dalimov D.N., Kurmukov A.G., Salikhov Sh.I. “A medication demonstrating anti-hypoxic activity”.
- Patent UZ № IАР 04666, 23.03.2013. Salikhov Sh.I., Mavlyanov S.M., Karamov E.V.“A medication demonstrating anti-HIV activity”.
- Patent UZ № IAP 04806.Patent application IAP 2009 0404.Preparation of 3,15,16,18-tetrahydroxy-9,3-epoxy labdan with polyvinyl pyrrolidine with hemostatic effect. Sh.I. Salikhov, D.N. Dalimov, A.D. Matchanov, M.B. Gafurov, N.L. Vypova
- Patent UZ № IАР 05109, Patent application IAP 2013 0214. Nazyrov F.G., Saidkhanov B.A., Alimov M.M., Dalimov D.N., Makhmudov K.O., Matchanov A.D., Azimova T.M., Nigmatov Sh.K. “A collagen-based hemostatic film”.
- Patent UZ № IAP 05090; Patent application IAP 2013 0241. Method to control the cotton wilt. A.A. Akhunov, N.R. Khashimova, E.A. Pshenichnov, V.A. Avtonomov, D.N. Dalimov, A.D. Matchanov, M.B. Gafurov
- Patent UZ № IАР 20160404, 29.09.2016. Asrarov M.I., Mavlyanov S.M., Shkinyov A.V., Pozilov M.K., Makhmudov R.R., Abdulladjanova N.G., Ergashev N.A., ABdullaeva G.T., Salikhov Sh.I. “An antidiabetic medication”.
Publication
- Borisova M.P., Kataev A.A., Mavlyanov S.M., Abdulladjanova N.G. Effect of hydrolyzing tannin on native and superficial biological membranes. Biological Membranes, 2014, Vol. 31, No.4, 278-287.
- E. Olchowik-Grabarek , I. Swiecicka, Z. Andreeva-Kovaleskaya, A. Solonin, D.Bonarska-Kujawa , H. Kleszczynska, S. Mavlyanov, M. Zamaraeva «Role of Structural Changes Induced in Biological Membranes by Hydrolysable Tannins from Sumac Leaves (Rhus typhina L.) in their Antihemolytic and Antibacterial Effects»//J Membrane Biol., 2014, Р.533–540.
- A.M. Asrorov, J.F. Ziavitdinov, E.M. Sultanova, O.N. Veshkurova, A.D. Matchanov, Sh.I. Salikhov.Comparative effects of various insecticides on the levels of free amino acids, nitrogen and potassium in the cotton leaves. Uzbek Chemical Journal, Tashkent, 2014, No.1, 49-52.
- А.Ergashev, R.Eshchanov, G.Yakubov,А. Rakhimov, N. Turdieva, N. Turaeva, Kh.Urinova, А. Matchanov. Cultivation of drug-dye plant indigofera variety «Feruz -1» for the re-cultivation in degraded lands of Aral Sea Region. J. Chem. Chem. Eng. 8 (2014) 707-716.
- Dalimov D.N., Vypova N.L., Matchanov A.D., Saidkhanov B.A., Alimov M.M., Islamov A.Kh., Gafurov M.B. Hemostatic medications based on lagochilin, a diterpenoid. Bulletin of Uzbekistan National University, 2015, No.3/1, 208-218.
- ChorievaN.M., KhamidovaJ.J., KurbannazarovaR.Sh., MerzlyakP.G., NuritdinovaN.S., MatcanovA.D., GafurovM.B. Study on gossypol and its effects on the human erythrocyte lysis. Bulletin of National University of Uzbekistan, 2015, No.3/1, 49-51
- 6.ChorievaN.M., KhamidovaJ.J., KurbannazarovaR.Sh., MerzlyakP.G., NuritdinovaN.S., MatcanovA.D., GafurovM.B., Tashmukhamedov B.A., Sabirov R.Z. Effects of gossypol and batriden on the human erythrocytes under osmotic stress. Bulletin of National University of Uzbekistan, 2015, No.3/1, 52-54
- 7.J. Mirsoatov, E. Berdiev, A. Matchamov. Lagochillus Inebrians management practice.Bulletin of Uzbekistan agrarian science. 2015, 1(59), 7-10
- Eshbaev A.A., Aimenov J.E., Matchanov A.D., Islamov A.Kh. Results of comparative study on macro- and microelement composition of Lagochilus Intbriansand Lagochilus Setolosus.Bulletin of Kazakhstan National University (Alma-Ata), 2015, 2/1 (64), 13-19.
- А. Ergashev, G. Yakubov, А. Matchanov, N. Turaeva, Development of biotechnology of dye & of drug plant indigofera variety «Feruz -1» for the improving of sale lands of the Aral Sea Basin. International Journal of Development Research, Vol.5.issue 12. pp 6213-6218.December. 2015.
- Borisova M.P., Kataev A.A., Mavlyanov S.M., Abdullajanova N.G.Effects of Hydrolysable Tannins on Native and Artificial Biological Membranes//Membrane and Cell Biology, 2015, Vol. 9, No. 1, pp. 53–60.
- Кhoshimov N.N., Rakhimov R.N.,Nasirov K. E.Research of action of preparation rutan on various sites of GABA-receptor at chronic alcoholic intoxication.// Eastern European Scientific Journal.Dusseldorf – Germany.Ausgabe №3. 2015. P.-32-37.
- Кhoshimov N.N., Rakhimov R.N.,Nasirov K. E. The Research of Action of Preparations Rutan and Gossitan on the Glutamate Eksitetoxic Mediated by NMDA-receptor at Chronic Alcoholic Intoxication and Cancellation of Ethanol// Russian Journal of Biological Research, 2015. V. 4. P.- 60-65.
- Khushmatov Sh.S., Makhmudov R.R., Mavlyanov S.M., Abdukulov Z.U. Short pharmacological characterization and cardioactivity of some phenolic compounds, Bulletin Gulistan State University, 2015, No.4, 17-21.
- Khushmatov Sh.S., Makhmudov R.R., Rustamov Sh.U. Polyfunctional pharmacological effect of great plantain (Plantago major L).Infection, Immunity and Pharmacology, 2015, No.2, 189-197
- Khushmatov Sh.S., Makhmudov R.R., Mavlyanov S.M. Comparative study on inotropic and antiarrhythmic activity of flavonoids, quercetin, rutin and (+) catechin. Russian Cardiological Journal, 2015, No.11, 35-41 http://russjcardiol.elpub.ru/jour/ article/view/452
- 17.E.Оlchowik-Grabarek, S.Mavlyanov, N.Abdullajanova, R.Gieniusz, M.Zamaraeva. Specificity of hydrolysable tannins from Rhus typhina L. to oxidants in сell and cell-free models// Appl Biochem Biotechnol. DOI 10.1007/s12010-016-2226-1. Published on line 06 September 2016
- S.Sękowski, M.Ionov, A.Dubis, S.Mavlyanov, M.Bryszewska, M.Zamarajewa. Biomolecular Interactions of Tannin Isolated from Oenothera gigas with Liposomes// J. Membrane Biol (2016) 249:171-179.
- Makhmudov R.R., Abdulladjanova N.G. Phenolic compounds from Plantago lachnantha.Bulletin of National University of Uzbekistan. 2016, No.3/2, 253-256.
- Rakhimov R.N., Abdulladjanova N.G., Mavlyanov S.M. Polyphenols from plants of the Еuphorbiaceaefamily. Bulletin of National University of Uzbekistan. 2016, No.3/2, 280-283.
- Rakhimov R.N., Abdulladjanova N.G., Mavlyanov S.M. Chemical composition of Euphorbia Humufusa. Bulletin of National University of Uzbekistan, 2016, No.3/2, 256-259.
- Makhmudov R.R., Abdulladjanova N.G. Chemical composition and biologic activity of Plantago gentianoides sibth. Bulletin of National University of Uzbekistan. 2016, No.3/2, 256-259.
- Rakhimov R.N., Abdulladjanova N.G., Mavlyanov S.M. Chemical composition of Euphorbia сanescens L.Doklady Akademii Nauk Respubliki Uzbekistan, 2016, No.5, 50-56
- 24.Makhmudov R.R., Abdulladjanova N.G., Mavlyanov S.M. Flavonoids from Рlantago coronopus l.Doklady Akademii Nauk Respubliki Uzbekistan, 2016, No.5, 63-64
- Makhmudov R.R., Abdulladjanova N.G., Mavlyanov S.M. Flavonoids from Plantago logocecephala bge. Doklady Akademii Nauk Respubliki Uzbekistan, 2016, No.5, 71-74
- Sekowski S., Ionov M., AbdullajanovaN., Makhmudov R., Mavlyanov S., Milowska K., Bryszewska M. Zamaraeva M. Interaction of α-synuclein with Rhus typhina tannin – Implication for Parkinson’s disease Interaction of α-synuclein with Rhus typhina tannin – Implication for Parkinson’s disease// Colloids and Surfaces B: Biointerfaces 155 (2017) 159–165.
- Оlchowik-Grabarek E., AbdullajanovaN., Mavlyanov S., Gieniusz R., Zamaraeva M. Specificity of hydrolysable tannins from Rhus typhina L. to oxidants in сell and cell-free models// Appl Biochem Biotechnol. 2017, Volume 181, Issue 2, pp 495–510.
- Rakhimov R.N., Abdulladjanova N.G., Mavlyanov S.M. Polyphenols from Euphorbia Himufusa. Doklady Akademii Nauk Respubliki Uzbekistan, 2017, No.1, 48-50
- Rakhimov R.N., Abdulladjanova N.G., Mavlyanov S.M. Chemical composition of Euphorbiacanescens (L.). Doklady Akademii Nauk Respubliki Uzbekistan, 2017, No.5, 50-56
- Gayibov U.G., Komilov E.J., Rakhimov R.N., Ergashev N.A., Abdulladjanova N.G.,Asrarov M.I., Aripov T.F. Effect of ps-1 polyphenolic compound on the permeability of membranes of rat liver mitochondria//Doklady Akademii NaukRespubliki Uzbekistan, 2017, No.5, 15-19
- Gayibov U.G., Komilov E.J., Rakhimov R.N., Ergashev N.A., Abdulladjanova N.G.,Asrarov M.I.,Aripov T.F. Antioxidant and membrane-active features of ps-1 polyphenolic compound//Uzbek Biological Journal, 2017, No.2, 19-23.
- Jumaev I.Z., Usmanov P.B., Khushmatov Sh.S., Rustamov Sh.Yu., Rakhimov R.N. Effect of 3,3',4',5,7-pentahydroxyflavon on the function of cardiac myocyte B-adrenoreceptor under experimental (in vitro) hypoxia. Infection, Immunity, pharmacology, 2017, No.4, 56-59
- Matchanov A.D., Usubbaev A.M., Islamov A.KH., Tashpulatov F.N., Matchanov U.D., Esanov R.S. Development of HPLC method for the quantitative determination of Glylagin tablets. International Scientific and Practical Conference. World Sciences, No. 4 (20), Vol.5 April 2017, 34-37
- Matchanov A.D., Dalimov D.N., Zainutdinov U.N., Vypova N.L., Islamov A.Kh., Bekpolatova B.M. Generation and study on physical-chemical and biological properties of molecular accociates of lagochilin and lagochirzin with glycerrhyzic acid and its monoammonia salt. Chemistry of Natural Compounds, 2017, No.4, 455-570
- Saidkhanov B.A., Turakulov A.B., Dalimov D.N., Matchanov A.D. “Glylagin”, a new collagen film in parenchymatous hemorrhages. Emergency Medicine Bulletin, 2017, No.4
- Saidkhanov B.A., Butaev A.Kh., Makhmudov K.O., Matchanov A.D. Morphological analysis of “Glylagin” hemostatic film in experimental modeling of liver hemorrhages. SurgeryofUzbekistan, 2017, No.4, 40-43.
- Кhoshimov N. N., Rakhimov R.N., Akhmedova G.B.,Azizov V.G. Investigation of the Effect of Polyphenol Euphorbin on the Transport of L Glutamate and Calcium Channels to Synaptosomes of Rat Brain// European Journal of Medicine. Slovakia. 2018, 6(2): 72-82.
- Gayibov U.G., Gayibova S.N., Komilov E.J., Rakhimov R.N., Ergashev N.A., Asrarov M.I., Aripov T.F. Anti-radical activity of polyphenol compounds isolated from the Euphorbia family plants. Universum. Technical Sciences, 2018, No.1, 60-63.
- Gayibov U.G., Komilov E.J., Takhimov R.N., Ergashev N.A., Abdulladjanova N.G., Asrarov M.I., Aripov T.F. Effect of ps-1 polyphenol compound on the permeability of membranes of rat liver mitochondria. Doklady Akademii Nauk Respubliki Uzbekistan, 2018, No.1, 60-66.
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